(Head of Department of Systems and Computational Biology)
F-50, Laboratory of Computational Biology
School of Life Sciences, University of Hyderabad (P.O. Central University)
Prof. Nagarajaram obtained his PhD in 1995 under the mentorship of Prof. C.Ramakrishnan, Molecular Biophysics Unit (MBU), Indian Institute of Science (IISc), Bengaluru. Soon after PhD he joined Prof. Sir Tom Blundell’s group at the Department of Biochemistry, University of Cambridge, England, and carried out his post-doctoral work from 1996 to 2000. In 2000 he returned to India and joined CDFD as Staff Scientist and established the Laboratory of Computational Biology (LCB). At CDFD he was also holding an additional responsibility of heading its Bioinformatics Facility and served as the India Node Manager of EMBnet as well as the elected member of the Executive Committee of theM ASEA-PACIFIC Bioinformatics Network (APBioNet). In Feb, 2017, he accepted the Professor position in the School of Life Sciences (SLS), University of Hyderabad (UoH) and moved LCB to the SLS premises. Since the last quarter of 2018 he has been made the first Head of the newly formed Department of Systems and Computational Biology (DoSCB) as well as the Professor-in-Charge of Centre for Modelling, Simulation and Design (CMSD) .
His research mainly focuses general and fundamental features and design principles of structures and interactions of human proteins and their disease variants. His group works in the following research areas :-
Computational Systems Biology:
Protein structure prediction and modelling
Prokaryotic Genome Analysis
He has so far mentored eight students for their PhDs who are currently working as postdocs/independent researchers in
some of the very prestigious institutes in India, US and UK.
He is currently mentoring six students for their PhD doctoral work. In addition he has also guided about 30 Masters/B.Tech. students for their project works.
He has published more than 70 papers in the international high-impact, peer-reviewed journals such as Human Mutation, Journal of Proteome Research, Bioinformatics, Nucleic Acids Research, Journal of Molecular Biology, PNAS, Protein Science, Protein Engineering etc.
He has been teaching courses in Bioinformatics, Computational Biology, Computational Systems biology, Mathematics and statistics. He has been serving as a member of Board of studies in some central and state universities.
The details of the courses offered by me are as follows:
|Sl.no.||Course ID||Course Title||Credits|
|1||FN108/BT406||Basics in Mathematics and Statistics (Theory)
||3 (only in 2017) 2 (2018 onwards)|
|2||BI501||Basic Mathematics and Statistics for Bioinformatics||3|
|3||Ph.D. Course||Module IV: Protein dynamics and modeling
||6 hrs (0.5 credit)|
|Sl.no.||Course ID||Course Title||Credits|
|1||BI 712/BI552||Computational Systems Biology (Theory)
||3(1.5 since 2019)|
|2||BI717/BI556||Computational systems biology (Practicals)
||2(1 since 2019)|
Invited Lectures (only recent ones since 2017) :
|1||Network analysis in identification of drug targets||National workshop on drug design and discovery, Institute of Life Sciences, Bhuvaneshwar, Orissa||20 March 2017|
|2||Network representation of protein-protein interactions: What do we learn from it?||UGC Refresher course: Gave a talk on “Protein-protein interaction networks” , University of Hyderabad, Hyderabad||24 August 2017|
|3||Protein structure prediction and modelling||Training Programme on Application of Bioinformatics in Agricultural Research and Education NAARM, Hyderabad||16 September 2017|
|4||Protein protein interaction network analysis and target selection toward drug design||GIAN workshop, School of Life Sciences, University of Hyderabad, Hyderabad||1st September 2017|
|5||The Dichotomy of Hubs in Protein-Protein Interaction Networks||Inbix'17: Indian Conference on Bioinformatics 2017 Birla Institute of Scientific Research Jaipur||November 7-9, 2017|
|6||Analysis of Human-viral protein-protein interaction networks||10th National Symposium cum Workshop on “Recent Trends in Structural Bioinformatics and Computer Aided Drug Design” [SBCADD’2018] and 1st Annual Meeting of Bioinformatics and Drug Discovery Society (BIDDS), Alagappa University, Karaikudi, Tamilnadu||20th - 23rd February, 2018|
|7||Intrinsically Disordered Regions Proteins Harbouring Disease Causing Missense Mutations||BSBE Annual Winter Workshop, IIT Kanpur (Practicals)||December 7-9, 2018|
|8||Amino acid substitution scoring matrices appropriate for alignment of proteins enriched with intrinsically disordered regions||10th Annual Meeting of the Proteomics Society, India (PSI) and International Conference on “Proteomics for Cell Biology and Molecular Medicine” National Centre for Cell Science (NCCS), Pune, India||December 12th to 14th, 2018|
Extramural Funding (on-going):
|1||NCDs-CAPomics: Exploring the Volatome of NonCommunicable Diseases as a Promising Non-Invasive and Integrating Approach for its Rapid Diagnostics. The Case Study of Cancer and Neurodegenerative Diseases||INNO INDIGO Partnership Programme Call on “Diagnostics and interventions in Chronic non-communicable diseases” Department of Science & Technology (DST) India||2016-19|
|2||Chemical and genomic approaches to investigate possible link between development of antimicrobial resistance (AMR) and pharma industry effluents||Bulk Drug Manufacturers Association of India (BDMAI), C-25, Industrial Estate, Sanathnagar, Hyderabad - 500 018||2019-20|
|Mobile:||+91-(0) 990 820 9193|